The excitement about the potential opportunities for leveraging data by means of advanced analytics is huge. But, the honeymoon between business and data science is over. Stakeholders want to see value generation from data science. At Roche Diagnostics the Data Science Lab was created. Its mission is to explore business opportunities for data science across the company and to deliver productive, algorithm based systems that create impact. In his keynote, Frank will present some examples of data science initiatives going from data exploration over predictive modelling to productionization. Some of the challenges encountered will be addressed as well as the learnings.